Life Science Filter

Protecting Life with Biosecurity Filtration

Depth Filter ZetaCARE

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    Feature_Tec ZetaCARE depth filter boasts a stable, reliable, and powerful liquid clarification capability. The filter media is composed of wood cellulose, inorganic filter aids, and charged resins through a multi-step composite process. 
    The three-dimensional interwoven structure within the filter media effectively removes particles, cell debris, and other insoluble impurities, providing the first line of defense for efficient liquid clarification. 
    The uniformly distributed charges can effectively remove residual DNA and host cell proteins (HCP) and other soluble impurities, providing a second line of defense for efficient liquid clarification. 
    The dual overlapping protection ensures robust support for efficient liquid clarification, reducing the downstream purification load, helping customers shorten process times, lower production costs, and increase economic benefits.

     

     

    Features

    • Filter media composed of wood fibers and inorganic filter aids
    • Three-dimensional structure with progressively finer filtration layers.
    • High throughput, high capacity, and high retention rate.
    • Balanced pressure control ensures consistent precision across batches, enabling reliable operational processes.
    • Available in both positively and negatively charged versions to meet diverse customer clarification needs.

     

     

    Typical applications

    • Clarification filtration of fermentation broths or cell culture fluids
    • Clarification filtration after virus inactivation
    • Clarification filtration of blood and serum products
    • Filtration of enzyme preparations
    • Clarification filtration of plasmids or viruses

     

     

    Feature ZetaCARE Process Development (PD) ZetaCARE Lab-Scale (LS) ZetaCARE Production-Scale (PS)
    Filtration Layer Double Layer Double Layer Double Layer
    Housing Material PP PP Glass Fiber-Filled Polypropylene
    Filter Sheet Cellulose, Filter Aids, Resin Cellulose, Filter Aids, Resin Cellulose, Filter Aids, Resin
    Support Layer PP PP PP
    O-Ring / / Silicone
    Effective Filtration Area 23 $cm^2$ 270 $cm^2$, 540 $cm^2$ 0.11 $m^2$, 0.55 $m^2$, 1.1 $m^2$
    Dimensions (cm) 8.9 $\times$ 6.6 $\times$ 4.1 22 $\times$ 14 $\times$ 7.9 / 9.4 61 $\times$ 33 $\times$ (2.94 / 7.4 / 12.4)
    Outlet, Vent Ports Luer Ports: Polycarbonate 6mm Hose Barb Flat Seal (TPE)
    Max. Operating Pressure 3.0 bar @ 20°C 3.0 bar @ 20°C 3.0 bar @ 20°C; 1.0 bar @ 80°C
    Max. Forward D.P. 2.1 bar @ 20°C 2.1 bar @ 20°C 2.1 bar @ 20°C; 1.0 bar @ 80°C
    Max. Reverse D.P. 1.0 bar @ 20°C 2.1 bar @ 20°C 2.1 bar @ 20°C
    Sterilization Tolerance Integrity remains unchanged after 2 cycles of 60 min @ 121°C Integrity remains unchanged after 1 cycle of 60 min @ 121°C Integrity remains unchanged after 1 cycle of 60 min @ 121°C
    Indirect Food Additives Complies with FDA standards (21 CFR 177-182) Complies with FDA standards (21 CFR 177-182) Complies with FDA standards (21 CFR 177-182)
    Toxicity Complies with USP <88> Class VI Biocompatibility tests Complies with USP <88> Class VI Biocompatibility tests Complies with USP <88> Class VI Biocompatibility tests
    Bacterial Endotoxins Filter Media: <0.25 EU/mL (USP <85> LAL method) Filter Media: <0.25 EU/mL (USP <85> LAL method) Filter Media: <0.25 EU/mL (USP <85> LAL method)
    Conductivity <20 μS/cm after rinsing with 100 L/$m^2$ purified water* Same as PD Same as PD
    TOC <5 ppm after rinsing with 100 L/$m^2$ purified water* Same as PD Same as PD
    Non-volatile extractables NVR levels ≤ 4% of cardboard's mass after standard extraction Same as PD Same as PD

     

Depth Filter ZetaCARE
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  • Depth Filter ZetaCARE

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