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Life Science Filter

Protecting Life with Biosecurity Filtration

LOPAC PF Bioburden Control Filter

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LOPAC PF Filter membrane is made of hydrophilic polyethersulfone membrane (PES) with good hydrophilicity and low protein adsorption. It is suitable for the bacteria-reducing filtration of bioprocess fluids with easy adsorption and complex ingredient, It can reduce the microbial contamination level and meet the process requirements.

Product Feature

• Unique double layer design

• Reliable bacterial and particulate retention

• Excellent chemical compatibility (pH: 1-14)

• Less dissolution

• Low protein adsorption

Applications

• Decontamination of cell culture media
• Filtration of buffers
• Pre-column / Pre-ultrafiltration protection

Product Parameters

Filter Type

dish filter

capsule filter

Cartridge filter

Nominal size (inches

φ50mm

2.5

Specifications

2.5

Filtration area
(M²)

single layer

15cm²

180cm ²

0.073

0.23

0.63

D63
D70

0.11
0.15

0.23
0.30

0.45
0.60

0.90
1.20

1.35
1.80

double layer

15cm²

160cm ²

0.065

0.20

0.60

D63
D70

0.11
0.15

0.23
0.30

0.45
0.60

0.90
1.20

1.35
1.80

filter pore size

0.65μm 0.22μm .22μm .22μm . 2μm 0.22μm·0.8μm·············································································································· 2μm 0.45μm

Structure material

Support layer: Polypropylene (PP)
Housing/End caps/Fins: Polypropylene (PP)
Interface: Polypropylene (PP),222/226 with built-in stainless steel reinforcement
Sealing ring: silicone rubber/EPDM/fluorine rubber/fluorine rubber
Hot melt technology: hot melt sealing without adhesive
Membrane material: hydrophilic polyethersulfone (PES)

Maximum operating differential pressure

Forward

2bar(29psi)@ 20 ℃

L 、 M:5bar(72.5psi)@ 20℃
3bar(43.5psi)@50℃

5bar(72.5psi)@25℃
2bar(29psi)@ 80 ℃

S:4bar(58psi)@20℃
2bar(29psi)@ 50 ℃

Reverse

2bar(29psi)@ 20 ℃

2bar(29psi)@ 20 ℃
1.5bar(22psi)@50℃

2bar(29psi)@ 25 ℃

Sterilization method

Resistant to high pressure steam sterilization and irradiation sterilization

High pressure steam sterilization: 134 ℃ * 30min * 25 times
Irradiation sterilization:<50 kGy

High pressure steam sterilization: 134 ℃ * 30min * 25 times
Online steam sterilization: 134 ℃ * 30min * 25 times (△p≤ 0.3bar)

biological safety

The structural components of this filter element meet the current USP<88> Class VI plastic biosafety requirements

Cleanliness

Meet the requirements of FDA21CFR211.72 and 210.3 (B)(5)(6) for non-fiber shedding filters, and the level of insoluble particles in the flushing fluid meets the requirements of USP<788>

Toxicity of ingredients and materials

Comply with USP<88> Response Test for Class V Plastics

endotoxin

The endotoxin level of the filter element flushing fluid tested by gel method <0.25EU/mL meets the requirements of USP<85>

integrity

100% of each cartridge/filter passed the integrity test before leaving the factory

Production Environment

All in one hundred thousand clean workshop production

Typical Applications

Antibiotic Filtration

Vaccine Filtration

Monoclonal Antibody Purification

Related components

Related Equipment

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