Filtration & Separation Solutions

Embrace Ultimate Application Challenges of Filtration, Separation, and Purification Technology

Antibiotic Filtration

In the pharmaceutical industry, antibiotic production predominantly relies on fermentation methods. The solution produced during fermentation often has a low concentration of antibiotics. Typically, purification and concentration are carried out using techniques like solvent extraction and thin-film evaporation after filtering to remove biological residues and resin decoloration.

 

Filtration and pretreatment of the fermentation broth serve the purpose of not only separating mycelium but also removing certain impurities. Antibiotics exist in the fermentation broth when fermentation is complete, but there are some specific cases that a significant amount of antibiotics remains in the mycelium. In such instances, pretreatment of the fermentation broth should include the precipitation of antibiotics from the mycelium, transferring them into the fermentation broth.

 

Fermentation Broth Filtration: The fermentation broth is a non-Newtonian liquid, making it difficult to filter. The ease of filtration depends on factors such as the fermentation medium, process conditions, and whether contamination has occurred. When using inappropriate filters such as plate and frame filters, the process becomes labor-intensive, raises hygiene concerns, and poses challenges in wastewater treatment, particularly when mycelium flows into the sewer.

 

Feature-tec Solution:

At Feature-Tec, we provide comprehensive pharmaceutical filtration solutions. Our experienced filtration experts thoroughly understand your process requirements and recommend suitable filtration systems. From deep pre-filtration to terminal sterile filters, Feature-Tec products are widely used in clarification, sterilization, and vent filtration processes, ensuring a more economically reliable pharmaceutical production process.

 

Clarification and Sterile Filtration

Clarification filtration is used in the pharmaceutical industry to reduce particulate matter and biological load. Controlling biological load during pharmaceutical processing is crucial for maintaining product quality and improving overall process economics. Clarification filtration takes various forms, with diverse equipment options available. Feature-Tec can provide automated complete equipment systems and disposable filters.

 

Pre-filters are often used in conjunction with sterile filters to help protect and extend the lifespan of downstream sterile filters. In some non-sterile applications, pre-filters are used independently to safeguard downstream equipment or as a safety filtration step in the process. Feature-Tec offers a variety of filtration precisions and membrane materials to suit different process requirements.

 

Benefits include:

• Effective reduction of biological load

• Increased product yield

• Long filter lifespan

• Efficient protection of downstream sterile filtration

• Filters chemically compatible with pharmaceutical liquids

 

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